|  |  | November 4, 2009  The long-term use of prescribed anti-acids is on the rise. Research has shown that acid reflux, heartburn, and dyspepsia may be caused by the very medication meant to control them and that long-term use of them could be forming dependence on the drugs.
Dr. Christina Reimer, MD, Copenhagen University, noted, "The observation that more than 40% of healthy volunteers, who have never been bothered by heartburn, acid regurgitation or dyspepsia, develop such symptoms in the weeks after cessation of PPIs is remarkable and has potentially important clinical and economic implications."
Her team gave PPIs (proton pump inhibitors) to participants who had no symptoms of heartburn or acid reflux until after they began using the drug.
120 healthy adults were divided into two groups and administered either a placebo for 12 weeks or esomeprazole (a PPI) for eight weeks followed by 4 weeks of placebo. Their gastric symptoms were recorded weekly according to the Gastrointestinal Symptom Rating Scale (GSRS).
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