Adult Stem Cells... details and FAQs

Stem Cell Nutrition #4
Adult Stem Cells...

details and FAQs

This is letter 4 in a series on adult stem cells and your health.

In this letter, several different recent studies using stem cells are quoted; this will help bring a real sense of how important stem cells are to our health in general, and especially in preventing premature aging and aging diseases.

Plus, you get a chance to see how simple; easy; and LOW COST our product is, compared to the other adult stem cell therapies in use today!

MISCELLANEOUS STEM CELL FACTS AND SOURCES

NEW YORK (Reuters Health) - In a small study, a treatment that included stem cell transplantation induced prolonged insulin independence in patients with newly diagnosed type 1, or insulin-dependent, diabetes.

In a statement, lead author Dr. Julio C. Voltarelli, from the Regional Blood Center in Ribeiro Preto, Brazil, called the results "very encouraging."

While the same approach has been used in other autoimmune disorders, the current study, to the author's knowledge, represents the first time the approach has been used in human type 1 diabetes.

In type 1 diabetes, a person's immune system attacks and destroys insulin-producing beta cells in the pancreas. Preserving beta cells is a key concept in the management of type 1 diabetes and in the prevention of its related complications.

Voltarelli's team tested the ability of high-dose immune suppression and stem cell transplantation to preserve beta cell function in 15 patients who were diagnosed with type I diabetes in the previous 6 weeks. All of them required insulin.

Stem cell transplantation involves the harvesting and treatment of a patient's own stem cells and then returning them to the patient via intravenous injection.

During follow up, 14 patients became insulin-free -- 1 for 35 months, 4 for at least 12 months, and 7 patients for at least 6 months. Two "late responders" were insulin-free for 1 and 5 months, respectively.

While further study is needed, Dr. Jay S. Skyler, from the University of Miami, comments in a related editorial, "the time may indeed be coming for starting to reverse and prevent type I diabetes."

Journal of the American Medical Association, April 11, 2007.

Living Forever?

There is potential for humans to mimic the biologically immortal hydra, by exploiting our stem cells in the regeneration of organs damaged by age-related diseases. The=2 ability of adult stem cells, which remain in the body throughout life, to regenerate heart muscle cells has already been demonstrated in mice. Organs regenerated this way would in effect be brand new, and "younger" than all the other tissues and organs. Such regeneration might not immediately boost life's span, but should greatly improve its quality in old age.

Stem cells may fix brain

Research in mice suggests that neural stem cells may be more effective in repairing damaged brain tissue than previously believed, a finding that could lead to new treatments for stroke and other brain trauma in humans.
University of California, San Francisco researchers found that neural stem cells from the brain's subventricular zone quickly repaired damaged cerebral tissue in newborn mice, Agence France Presse reported.

Reverse your age

How far back can the clock go for stem cell patients? Ideally five to 10 years. And if, as Dr. Maffetone says in his book In Fitness and In Health, people improve the quality of their lives through healthy choices, the average human life expectancy can reach 120.

While most people want to age gracefully, others wish to improve the quality of their lives despite a health challenge.

Frequently Asked Questions about StemPlex

Who can use StemPlex?
The product is suitable for anyone who wants to support his or her body's natural renewal system.

Who should not use StemPlex?
There are no indications for anyone not to use Ste mPlex, but if you have a medical condition or are taking any prescription medication, we recommend that you consult with your health care professional.

Does StemPlex need to be taken with food or can it be taken by itself?
StemPlex can be taken with or without food. Taking StemPlex with food may slightly increase the absorption of fat-soluble substances like vitamin D.

Should you take both capsules of StemPlex at the same time?
It is best to take both capsules at the same time. StemPlex is formulated to match the concentration that was used in the research.

Is there any advantage to taking more than the recommended amount of two capsules of StemPlex per day?
We have no data b eyond the recommended amount of two capsules of StemPlex per day. We have no reason to believe that there is further benefit from taking more than two capsules per day. Since toxicity can occur from consuming large amounts of vitamin D, we don't recommend taking more than four capsules per day.

Is there caffeine in the green tea extract?
The green tea extract contains very little caffeine. In the final formula, the amount of caffeine is less than 2 mg per serving, or less than two-tenths of one percent. (As a comparison, an 8-oz cup of coffee contains 60 to 150 mg.)

What form of vitamin D is used in StemPlex?
Vitamin D3 (cholecalciferol) is the form of vitamin D used in this product. It is obtained from lanolin, an oil that is pressed from wool.

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What is the source of carnosine?
Carnosine is derived from a microbial fermentation process - similar to how fungal enzymes are produced. Carnosine is sometimes derived from feathers or hair, but after carefully researching this matter with our vendor, we determined that the carnosine we use is not derived from an animal source. It is derived from a microbial fermentation process.

Is the Aphanizomenon flos-aquae in StemPlex the same as that in a competitive product, StemEnhance?
StemPlex contains whole Aphanizomenon flos-aquae and other nutrients that have been shown to increase the proliferation of stem cells. StemEnhance is reported to contain two extracts of Aphanizomenon flos-aquae.

Does supplementing the use of StemPlex with enzymes help StemPlex become more available?
Although it is perfectly fine to take this product all by itself, it is true that using it in conjunction with enzymes will assist in the digestion and availability of the ingredients in StemPlex.

Does StemPlex stop working after a period of use?
Animal testing data suggests that the product works for continued periods of time, priming the stem cells to be ready when needed by the body.

StemPlex(T) by Simplexity

The Product

StemPlex is an all-natural stem cell proliferation product supported by an original research paper. StemPlex was formulated by leading university researchers who are world-class stem cell scientists. Their work is funded by the National Institutes of Health, the Veterans Administration, and other government sources.

Dr. Bickford and her colleagues demonstrated the proliferation effect of the ingredients included in the StemPlex formula on three types of adult stem cells in vitro.

The Research

The research showed that the combination of ingredients in StemPlex:

• Increased the proliferation of bone marrow cells by an average of 70%

StemPlex enhances cellular health in two ways:

1. It provides stem cell nutrition, as demonstrated in the proliferation effect.

2. Via its antioxidant capacity, the
formula protects existing stem
cells from the harmful effects of
free radicals; this is especially
important because during the
natural aging process, adult
stem cells are known to have
a reduced regenerative capacity.

The Results

This formula exhibits a synergistic effect, which means that the increase in number of new stem cells, from use of the formula, is greater than the increase that occurs through use of the ingredients individually. These ingredients are individually important in maintaining a healthy life style, but it is the unique and effective proprietary blend that supports your body's natural renewal system.

The research paper on this special product has been published in a peer-reviewed journal. This report is available for those who want the detailed technical information that supports this product's beneficial effects.

Even now, more research on this formula is in place, including human trials. The company is funding a three-year research program, and other stem cell-related products are in development.

The Ingredients

StemPlex's patent-pending formula contains six natural ingredients: a green tea extract, wild blueberry, carnosine, blueberry extract, vitamin D, and SBGA.

• Wild blueberry supports the health of the brain, heart, urinary tract, and eyes, as well as the proliferation of stem cells.
  
• Carnosine is an antioxidant amino acid naturally present in the human body that enhances the proliferation of stem cells and helps to protect against free radical damage. Carnosine may also delay the natural aging of cells and extend the lifespan of adult stem cells. The source of this Carnosine is 100% vegan!
  
• Blueberry extract enhances the proliferation of stem cells within the body, and promotes maintenance of healthy brain, cardiovascular, vision, 20 joint, and urinary tract function and normal glucose levels.
  
• Vitamin D3 supports adult stem cell renewal and helps these cells become immune cells for naturally fighting infections. The source is animal-friendly.
  
• Organic Super Blue Green® Algae is a freshwater algae, rich in protein, essential fatty acids, chlorophyll, beta-carotene, phycocyanin, phenylethylamine, vitamins, and minerals. It has a high antioxidant value, and has been shown to support the immune system.

Summary

• StemPlex is a natural product shown to increase stem cell proliferation by as much as 70%. Developed by reputable, leading stem cell scientists, StemPlex is supported by thei r original research report.
  
• Simplexity employs a first-rate Quality Assurance Program, and manufactures science-based, high-quality products

"How do you get world peace. You get world peace through inner peace.
If you've got a world full of people who have inner peace,
then you have a peaceful world." Dr. Wayne Dyer

"The doctor of the future will give no medication, but will
interest his patients in the care of the human frame, in diet,
and in the cause and prevention of disease."
—Thomas Alva Edison: Was an inventor and businessman

Carbohydrate Regulates Stem Cell Potency

ScienceDaily (Feb. 1, 2008) — Heparan sulfate, a carbohydrate molecule that coats certain proteins on the cell surface, is critical for the proper proliferation and potency of embryonic stem cells, researchers report.

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See also:

Health & Medicine

• Stem Cells
• Brain Tumor
• Malaria
• Lung Cancer
• Prostate Cancer
• Skin Cancer

Reference

• Embryonic stem cell
• Somatic cell
• Natural killer cell
• T cell

Stem cells' tremendous therapeutic potential arises from their ability to continually self-renew and turn into any adult cell type. Researchers have long been trying to uncover the basis of these abilities, but while several proteins and growth factors are known to play a role both inside and outside the cell, the molecular mechanisms remain largely unknown.

Many of the stem-cell associated can attach to heparan sulfate molecules, so Shoko Nishihara and colleagues examined what would happen to mouse stem cells in cell culture if heparan sulfate production was reduced or blocked. They discovered that three of the major external factors promoting stem cell renewal (proteins called Wnt, FGF, and BMP) could not induce the proper signals inside the cell without heparan sulfate (HS).

As a result, HS deficient cells grew more slowly, and also spontaneously differentiated into other cells more often, at rates that correlated with the level of inhibition. Nishihara and colleagues propose that heparan sulfate might be the cell-surface component that mediates the external and internal signals promoting stem cell renewal, and could be an important target for stem cell engineering.

Adapted from materials provided by American Society for Biochemistry and Molecular Biology, via EurekAlert!, a service of AAAS.

Need to cite this story in your essay, paper, or report? Use one of the following formats:

APA

MLA

American Society for Biochemistry and Molecular Biology (2008, February 1). Carbohydrate Regulates Stem Cell Potency. ScienceDaily. Retrieved February 2, 2008, from http://www.sciencedaily.com­ /releases/2008/02/080201131223.htm

Model displayes external factors that act to block stem cells from differentiating into different types of adult tissue. LIF activates STAT3 and blocks non-neural differentiation by induction of Myc, while BMP/Smad signaling through HS chains blocks neural differentiation by induction of Id. Wnt/b-catenin signaling through HS chains blocks primitive endodermal differentiation by induction of Nanog. FGF may contribute to proliferation through HS chains. HS chain dependent signaling by unknown factors may regulate proliferation and Oct3/4 expression. (Credit: Shoko Nishihara)

Extreme Stem Cell Nutrition

NATURE'S CARE FOR SELF REPAIR

While controversy surrounds embryonic stem cells, adult stem cells are a natural part of mature tissue. Adult stem cells are multi-potent cells found throughout the body. They have great potential to replace or repair almost every body part. Like movie actors, our own stem cells wait a casting call to tell them what role to play. Science is proving the right combinations of simple nutrients multiplies the growth of these "gifted actors".

Why Stem Cell Nutrition

• Research indicates adult stem cells may constitute the natural renewal system of the body.
• As you age, stem cell functionality declines, leaving your body more susceptible to injury and other age related health challenge.
• When every minute counts, support your body’s own “repair kit” with our stem cell nutrition breakthrough.

Each day millions of cells in your body die and are born. This is a natural process. It's the way our bodies are designed to renew and regenerate.

Proliferation of stem cells, plus a nutritious diet and exercise, will help give you the optimum health you deserve for a new look, a new you.

Developed by leading stem cell scientists, our product has shown to increase stem cell proliferation by as much as 70% in vitro.

“Synergy” of ingredients is the key.

Stem cell enhancers are products that support the natural role of adult stem cells. The combination of powerful antioxidants protect your cells from “free radical” damage, empowering our unique formula to support your stem cells in maintaining proper organ and tissue functioning in your body.

Whole foods and key nutrients help maintain the pure synergy and balance so vital to the human body. Science is proving the right combination of natural ingredients can boost adult stem cell growth up to 70% in vitro. When released, these stem cells may begin to work on areas of the body especially as we age. Synergy is the secret of creation and the secret of a long healthy life.

THE IMPORTANCE OF SYNERGY

Each nutrient in this new product boasts impressive qualities in its own right. Together, in precise amounts, simple nutrient compounds enhance each other's benefits. Quality nutrients interacting and acting simultaneously through multiple biological pathways and cellular mechanisms -- this is the power of synergy!

The success of traditional preparations depended on the precise gathering and blending of each component. Each enhanced the other, creating a powerful synergy that multiplied their holistic influence on the body, while simultaneously addressing a simple objective. Single plant formulas or plant isolates were rarely used. For longer periods of use they will generally influence a single pathway and become less effective than nutrient combinations that influence multiple cellular pathways. Some nutrients, for example, may provide cellular nutrition, decrease free radical toxicity or increase bio-availability.

Each ingredient in this product increases stem cells or enhances the growth. When combined, they significantly boost stem cell growth. In addition to this synergistic functioning, each ingredient adds unique benefits.

Green tea extract helps maintain the health of the digestive and respiratory systems, helps support normal cholesterol levels, and enhances the proliferation of stem cells in the body, especially within skin tissue.

Wild blueberry supports the health of the brain, heart, urinary tract, and eyes. Blueberry extract further promotes maintenance of healthy brain, cardiovascular, vision, joint and urinary tract function, and normal glucose levels in those whose levels are already normal.

Carnosine is an antioxidant amino acid naturally present in the human body that may delay the natural aging of cells and extend the lifespan of adult stem cells.

Vitamin D supports adult stem cell renewal and helps these cells become immune cells.

Wild-crafted micro-algae, a chlorophyll rich super food, strengthens overall nutritional balance and ease of assimilation.

Why Stem Cell Nutrition?

• Increases the growth of adult stem cells, as shown in in vitro laboratory studies.
• Supports the body’s natural renewal system through a unique combination of ingredients.
• Provides nutrition that enables stem cells to flourish.
• Protects existing stem cells from the harmful effects of free radicals.

by: Fran Allen
ExtremeStemCellNutrition.com

supports the body’s self-repair

In my humble opinion:

Stem - Plex is a nutritional supplement that supports the body’s self-repair mechanisms through the care of existing, and the proliferation of new, adult stem cells up to a 70% increase.

Modern science has proven that stem cells are essentially the building blocks of our body. Additionally, science has shown that adult stem cells are found in most organs, tissue, and especially bone marrow. These cells are pre-programmed to migrate toward problem areas within the body and begin a repair process. However, as our bodies age, adult stem cell production and efficacy lessen, and we in turn become more prone to illness or injury, which is commonly referred to as aging!

St em-Plex utilizes a specific combination of all-natural ingredients that are commonly taken by health-conscious individuals today. It is the patent-pending formulation of these ingredients that make Ste m-Plex unique. The ingredients in Stem-P lex work synergistically to positively impact the body’s stem cell nutrition. First, Stem-Pl ex encourages the proliferation of new adult stem cells. Stem cells are often referred to a “blank cells,” meaning that they begin to work on the problem areas of the body that often arise as we age. Second, the combination of all-natural ingredients along with antioxidants in Stem-Ple x work together to protect the body’s existing stem cells from the often harmful effects of free radicals.

Kay’s story:

For the past 50 years I have worn prescription glasses. In January 2007, I started taking Stem Cell Nutrition daily. In April 2007, I had my vision tested, as my glasses were no longer helping me to see. To my surprise my vision is now 20/20 in one eye and 20/16 in the other. That $800. I would have spent on new glasses can now be spent on Stem Cell Nutrition.

NutraStem® Science "Based on Science not Science Fiction"

NutraStem® - Science According to the U.S. National Institutes of Health, "an adult stem cell is an undifferentiated cell found among differentiated cells in a tissue or organ, can renew itself, and can differentiate to yield the major specialized cell types of the tissue or organ. The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found."

As we age, the number of adult stem cells within the body begins to decline and lose their ability to function normally, which is very important to maintaining a healthy immune system.

NutraStem® has been specifically formulated from natural compounds that promote the health and normal division (proliferation) of human adult stem cells.

In research that was published in a peer-reviewed journal article we examined the effects of several natural compounds that have been shown to promote healing for their ability to increase the health and normal division of human adult stem cells when grown in culture.

• We exposed three different types of adult stem cells, which are commonly found within the body, to natural compounds that are known to promote healing and measured the growth of these cells (Figure 1).
• Our results demonstrate a significant growth in the cells exposed to blueberry extract, green tea, catechin, carnosine and Vitamin D3, and that a specific combination of these ingredients at certain doses could promote even more growth of these stem cells.
• The control that was used to compare these effects was human granulocyte-macrophage colony-stimulating factor (hGM-CSF) which is used in humans to increase the numbers of stem cells in the blood.